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Among these, compound 2 (Figure 3) demonstrated the strongest inhibitory activity, with an IC 50 value of 6.57 M (94)

Zang M, Zuc collo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, and Cohen RA: AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells

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That magnitude is exactly why the muscle question matters: the more total weight you lose, the more total lean mass rides along with it